Our work is motivated by examples from two large cohort studies, the Generation R Study and the Rotterdam Study, in which the analysis models of interest involved non-linear effects, interaction terms or had a longitudinal outcome. As is the case for …
**Background:** Sentinel node biopsy (SNB) is essential for adequate melanoma staging. Most melanoma guidelines advocate to perform wide local excision and SNB as soon as possible, causing time pressure.
**Objective:** To investigate the role of time …