Appendix: PhD Portfolio & Curriculum Vitae

PhD Portfolio

Name PhD student: Nicole S. Erler
Department: Department of Biostatistics
Erasmus Medical Center Rotterdam
PhD period: 2014 – 2018
Promotors: Prof.dr. Dimitris Rizopoulos
Prof.dr. Emmanuel M.E.H. Lesaffre


year ECTS
at international conferences
35th ISCB conference, Vienna, Austria 2014 1.0
5th IBC Channel Meeting, Nijmegen, the Netherlands 2015 1.0
8th IBS EMR conference, Kapadokya, Turkey 2015 1.0
36th ISCB conference, Utrecht, the Netherlands 2015 1.0
28th IBS conference, Victoria, Canada 2016 1.0
37th ISCB conference, Birmingham, United Kingdom 2016 1.0
Joint Modeling and Beyond, Hasselt, Belgium 2016 1.0
9th IBS EMR conference, Thessaloniki, Greece 2017 1.0
38th ISCB conference, Vigo, Spain 2017 1.0
29th IBS conference, Barcelona, Spain 2018 1.0
Heidelberger Kolloquium, Heidelberg, Germany 2015 1.0
Erasmus Statistics Day, Rotterdam, the Netherlands 2016 1.0


year ECTS
Missing Values in Clinical Research (EP16), NIHES 2018 15
SPSS practical, MSc Medicine, Erasmus MC 2014 – 2018 1.3
Biostatistical Methods II (EP03), NIHES 2014 – 2018 1.4
Repeated Measurements (CE08), NIHES 2016 1.0


year ECTS
GAMLSS in Action (Erasmus MC, Rotterdam) 2014 0.6
INLA (IBC Channel Meeting, Nijmegen) 2015 0.1
Causal Questions and Principled Answers (ISCB, Vigo, Spain) 2017 0.3
Microbiomics I (MolMed, Erasmus MC) 2017 0.6
Bayesian non-parametric methods (Leuven, Belgium) 2017 1.0
Scientific Integrity (Erasmus MC) 2017 0.3
Network Meta Analysis with R (IBC, Barcelona, Spain) 2018 0.3
Bayesian Parametric and Nonparametric Methods for Missing Data and Causal Inference (Leuven, Belgium) 2018 1.0
DSMB training: To stop or not to stop, is that the question? (Erasmus MC) 2018 0.1

Seminars and Workshops

year ECTS
Erasmus MC bi-weekly Biostatistics / CQM seminar 2014 – 2018 1.0
Erasmus MC bi-weekly ErasmusAGE seminar 2014 – 2017 1.0
BMS-Aned Meeting, Rotterdam, the Netherlands 2014 0.2
BMS-Aned Meeting, Leiden, the Netherlands 2017 0.2
BMS-Aned Meeting, Amsterdam, the Netherlands 2017 0.2
BMS-Aned Meeting, Rotterdam, the Netherlands 2018 0.2


year ECTS
Statistical consultant in the Erasmus MC CPO system 2014 – 2018 16.0

Curriculum Vitae


since 2014 PhD in Biostatistics
Erasmus University Rotterdam, Rotterdam, the Netherlands
2013 – 2014 DSc Epidemiology
Netherlands Institute of Health Sciences, Erasmus Medical Center, Rotterdam, the Netherlands
2006 – 2012 Diplom Statistics
Ludwig-Maximilians-Universität München, Munich, Germany

Work Experience

since 03/2013 Scientific Researcher
Department of Biostatistics, Erasmus Medical Center, Rotterdam, the Netherlands
12/2012 – 02/2013 Scientific Researcher
Rotterdam Ophthalmic Institute,
Rotterdam, the Netherlands
11/2010 – 06/2011 Student Assistant
Central Examination Office for Natural Sciences, Ludwig-Maximilians-Universität München,
Munich, Germany
07/2008 – 11/2010 Student Assistant to Prof. Dr. Augustin
Department of Statistics, Ludwig-Maximilians-Universität München, Munich, Germany


2016 Student Award of the International Society for Clinical Biostatistics
2015 Student Award of the International Biometric Society (Eastern Mediterranean Region)

Collaborations and Consulting

since 2017 Collaboration with the Department of Gastroenterology and Hepatology, Erasmus Medical Center
statistical support for the planning and analysis of clinical trials, preparation of scientific manuscripts, analysis of data with advanced statistical methods
since 2014 Statistical consultant in the Consultation Center for Patient Oriented research, Erasmus Medical Center
providing statistical support to researchers within the Erasmus Medical Center
2013 – 2017 Collaboration with ErasmusAGE
(research group within the Department of Epidemiology, Erasmus Medical Center)
providing statistical support and collaboration on various research projects with focus on nutrition, lifestyle and healthy ageing


Alferink LJ, Kiefte-de Jong JC, Erler NS, de Knegt RJ, Hoorn EJ, Ikram MA, Janssen HL, Metselaar HJ, Franco OH, Darwish Murad S (2019). “Diet-dependent acid load - the missing link between an animal protein-rich diet and non-alcoholic fatty liver disease?” In press.

Alferink LJ, Radjabzadeh D, Erler NS, Vojinovic D, Gomez CM, Uitterlinden AG, de Knegt RJ, Amin N, Ikram MA, Janssen HL, Metselaar HJ, van Duijn CM, Kraaij R, Murad SD (2019). “Microbiomics, metabolomics, predicted metagenomics and hepatic steatosis in a population-based study of 1355 adults.” Manuscript submitted for publication.

Alferink LJ, Trajanoska K, Erler NS, Schoufour JD, de Knegt RJ, Ikram MA, Janssen HL, Franco OH, Metselaar HJ, Rivadeneira F, Murad SD (2019). “Non-alcoholic fatty liver disease in The Rotterdam Study: about muscle mass, sarcopenia, fat mass and fat distribution.” Journal of Bone and Mineral Research. doi: 10.1002/jbmr.3713 (URL:

Boor PP, Sideras K, Biermann K, Levink IJ, Mancham S, Erler NS, van Eijck CH, Bruno MJ, Sprengers D, Zang X, Kwekkeboom J (2019). “HHLA2 is expressed in pancreatic and ampullary cancers and increased expression is associated with better post-surgical prognosis.” Manuscript in preparation.

Coopmans EC, Schneiders JJ, El-Sayed N, Erler NS, Muhammad A, Hofland LJ, Petrossians P, van der Lely A, Neggers SJ (2019). “T2-signal intensity, SST receptor expression and first-generation somatostatin analogues efficacy predict hormone and tumor responses to pasireotide in acromegaly.” Manuscript in preparation.

De Wijs LE, Bosma A, Erler NS, Hollestein LM, Nijsten T, Spuls PI, Hijnen D (2019). “Dupilumab treatment for moderate-to-severe atopic dermatitis: daily practice data.” Manuscript submitted for publication.

Erler NS, Rizopoulos D, Jaddoe VW, Franco OH, Lesaffre EM (2019). “Bayesian imputation of time-varying covariates in linear mixed models.” Statistical Methods in Medical Research, 28(2), 555 - 568. doi: 10.1177/0962280217730851 (URL:

Erler NS, Rizopoulos D, Lesaffre EM (2019). “ Joint Analysis and Imputation of Incomplete Data in R.” Manuscript in preparation.

Hu C, Duijts L, Erler NS, Elbert NJ, Piketty C, Bourdès V, Blanchet-Réthore S, de Jongste JC, Jaddoe VW, Pasmans SG, Felix JF, Nijsten T (2019). “Most associations of early life environmental exposures and genetic risk factors poorly differentiate between eczema phenotypes. The Generation R Study.” British Journal of Dermatology. doi: 10.1111/bjd.17879 (URL:

Koolhaas CM, Kocevska D, te Lindert BHW, Erler NS, Franco OH, Luik AI, Tiemeier H (2019). “Objectively measured sleep and body mass index: a prospective bidirectional study in middle-aged and older adults.” Sleep Medicine, 57, 43 - 50. doi: 10.1016/j.sleep.2019.01.034 (URL:

Oey RC, Aarts P, Erler NS, Metselaar HJ, Lakenman PL, der Ree SRB, van Kemenade MC, van Buuren HR, de Man RA (2019). “Limited efficacy of recently proposed EASL criteria for identifying patients with malnutrition and sarcopenia in a population screened for liver transplantation.” Manuscript submitted for publication.

Oey RC, Buck LE, Erler NS, van Buuren HR, de Man RA (2019). “The efficacy and safety of rifaximin-\(\alpha\): a 2-year observational study of overt hepatic encephalopathy.” Manuscript submitted for publication.

Oey RC, van Tilburg L, Erler NS, Metselaar HJ, Spaander MC, van Buuren HR, de Man RA (2019). “The yield and safety of screening colonoscopy in patients evaluated for liver transplantation.” Hepathology. doi: 10.1002/hep.30562 (URL:

Overbeek KA, Kamps A, van Riet PA, Marco MD, Zerboni G, van Hooft JE, Carrara S, Ricci C, Gonda TA, Schoon E, Polkowski M, Beyer G, Honkoop P, van der Waaij LA, Casadei R, Capurso G, Erler NS, Bruno MJ, Bleiker EM, Cahen, D. L. On behalf of the Pancreatic CYst Follow-up: an International Collaboration (PACYFIC) study work group. (2019). “Pancreatic cyst surveillance imposes low psychological burden.” Manuscript submitted for publication.

Rauwers AW, Voor in ’t holt AF, Buijs JG, de Groot W, Erler NS, Bruno MJ, Vos MC (2019). “A nationwide risk analysis of duodenoscope and linear echoendoscope contamination.” Manuscript submitted for publication.

Van der Veer MA, Nangrahary N, Hesselink DA, Erler NS, Metselaar HJ, van Gelder T, Darwish Murad S (2019). “High Intra-Patient Variability in Tacrolimus Exposure Is Not Associated with Immune-Mediated Graft Injury after Liver Transplantation.” Transplantation. doi: 10.1097/TP.0000000000002680 (URL:

Van Riet PA, Larghi A, Attili F, Rindi G, Nguyen NQ, others (2019). “A multicenter randomized trial comparing a 25-gauge EUS fine-needle aspiration device with a 20-gauge EUS fine-needle biopsy device.” Gastrointestinal Endoscopy, 89(2), 329 - 339. doi: 10.1016/j.gie.2018.10.026 (URL:

Alferink LJ, Kiefte-de Jong JC, Erler NS, Veldt BJ, Schoufour JD, de Knegt RJ, Ikram AM, Metselaar HJ, Janssen HL, Franco OH, Darwish Murad S (2018). “Association of dietary macronutrient composition and non-alcoholic fatty liver disease in an ageing population: The Rotterdam Study.” Gut. doi: 10.1136/gutjnl-2017-315940 (URL:

Beelen EM, van der Woude CJ, Pierik M, Hoentjen F, de Boer K, Oldenburg B, van der Meulen A, Ponsioen C, Dijkstra G, Gijsbers A, Erler NS, Schouten W, de Vries. On AC, (ICC) C (2018). “Decreasing trends in ileocecal resections and postoperative surgical recurrence in Crohn’s disease: a nationwide cohort study in the Netherlands.” Manuscript submitted for publication.

Buschow SI, Biesta PJ, Groothuismink ZM, Erler NS, Vanwolleghem T, Ho E, Najera I, Ait-Goughoulte M, de Knegt RJ, Boonstra A, Woltman AM (2018). “TLR7 polymorphism, sex and chronic HBV infection influence plasmacytoid DC maturation by TLR7 ligands.” Antiviral Research, 157, 27 - 37. doi: 10.1016/j.antiviral.2018.06.015 (URL:

De Jonge EA, Rivadeneira F, Erler NS, Hofman A, Uitterlinden AG, Franco OH, Kiefte-de Jong JC (2018). “Dietary patterns in an elderly population and their relation with bone mineral density: The Rotterdam Study.” European Journal of Nutrition, 57(1), 61-73. doi: 10.1007/s00394-016-1297-7 (URL:

Didden P, Reijm AN, Erler NS, Wolters L, Tang T, ter Borg PC, Leeuwenburgh I, Bruno MJ, Spaander MC (2018). “Fully vs. partially covered selfexpandable metal stent for palliation of malignant esophageal strictures: a randomized trial (the COPAC study).” Endoscopy, 50(10), 961-971. doi: 10.1055/a-0620-8135 (URL:

Kamst NW, Mathijssen IM, Erler NS, van Veelen MC (2018). “Patient Reported Outcome Measurements in patients after scaphocephaly correction (PROM).” Manuscript submitted for publication.

Kanis SL, Modderman SC, Escher J, Erler NS, Beukers R, others (2018). “Long-term health outcomes of 1000 children born to mothers with Inflammatory Bowel Disease in the anti-TNF-\(\alpha\) era.” Manuscript submitted for publication.

Oey RC, de Man RA, Erler NS, Verbon A, van Buuren HR (2018). “Microbiology and antibiotic susceptibility patterns in spontaneous bacterial peritonitis: A study of two Dutch cohorts at a 10-year interval.” United European Gastroenterology Journal, 6(4). doi: 10.1177/2050640617744456 (URL:

Oey RC, de Wit K, Moelker A, Atalik T, Van Delden OM, Maleux G, Erler NS, Takkenberg B, De Man RA, Nevens F, van Buuren HR (2018). “Variable efficacy of transjugular intrahepatic portosystemic shunt (TIPSS) in the management of ectopic variceal bleeding: a multicenter retrospective study.” Alimentary Pharmacology & Therapeutics, 48(9), 975 - 983. doi: 10.1111/apt.14947 (URL:

Oey RC, van Buuren HR, de Jong DM, Erler NS, de Man RA (2018). “Bacterascites: A study of clinical features, microbiological findings, and clinical significance.” Liver International, 38(12), 2199 - 2209. doi: 10.1111/liv.13929 (URL:

Ottenhof MJ, Fani L, Erler NS, Castricum J, Obdam IF, van der Vaart T, Kushner SA, de Wit MY, Elgersma Y, Tulen J (2018). “Within-subject consistency of paired associative stimulation as assessed by linear mixed models.” bioRxiv. doi: 10.1101/434431 (URL:

Santosaningsih D, Erikawati D, Hakim IA, Santoso S, Hidayat M, Suwendha AH, Puspitasari V, Irhamni I, Kuntaman K, van Arkel A, Terlouw L, Oudenes N, Willemse-Erix D, Snijders S, Erler NS, Verbrugh HA, Severin J (2018). “Reducing transmission of methicillin-resistant Staphylococcus aureus in a surgical ward of a resource-limited hospital in Indonesia: an intervention study.” Manuscript submitted for publication.

Tielemans MJ, Erler NS, Franco OH, Jaddoe VW, Steegers EA, Kiefte-de Jong JC (2018). “Dietary acid load and blood pressure development in pregnancy: the Generation R Study.” Clinical Nutrition, 37(2), 597-603. doi: 10.1016/j.clnu.2017.01.013 (URL:

Vergouwe FW, IJsselstijn H, Biermann K, Erler NS, Wijnen RM, Bruno MJ, Spaander MC (2018). “High Prevalence of Barrett’s Esophagus and Esophageal Squamous Cell Carcinoma after Repair of Esophageal Atresia.” Clinical Gastroenterology and Hepatology, 16(4). doi: 10.1016/j.cgh.2017.11.008 (URL:

Brouwer J, Dolhain RJ, Hazes JM, Erler NS, Visser JA, Laven JS (2017). “Decline of ovarian function in patients with rheumatoid arthritis: serum anti-Müllerian hormone levels in a longitudinal cohort.” Manuscript submitted for publication.

Cepeda M, Schoufour JD, Erler NS, Marques-Vidal P, Franco OH (2017). “Influence of lifestyle markers and meteorological factors on the seasonality of cardiovascular risk factors: The Rotterdam Study.” Manuscript submitted for publication.

Garcia A, Erler NS, Jadooe VW, Tiemeier H, van den Hooven EH, Franco OH, Rivadeneira F, Voortman T (2017). “25-hydroxyvitamin D concentrations during fetal life and bone health in children aged 6 years: a population-based prospective cohort study.” The Lancet Diabetes & Endocrinology, 5(5), 367-376. doi: 10.1016/S2213-8587(17)30064-5 (URL:

Jaspers L, Erler NS, Fauser BC, Laven JS, Franco OH, Kavousi M (2017). “Towards a life-course approach in women’s healthy ageing: fertile lifespan characteristics are associated with a healthy ageing score in postmenopausal women of the Rotterdam Study.” Manuscript submitted for publication.

Jaspers L, Kavousi M, Erler NS, Hofman A, Laven JS, Franco OH (2017). “Fertile lifespan characteristics and all-cause and cause-specific mortality among postmenopausal women: The Rotterdam Study.” Fertility and Sterility, 107(2), 448-456.e1. doi: 10.1016/j.fertnstert.2016.11.006 (URL:

Jaspers L, Schoufour JD, Erler NS, Darweesh SK, Portegies ML, Sedaghat S, Lahousse L, Brusselle GG, Stricker BH, Tiemeier H, Ikram AM, Laven JS, Franco OH, Kavousi M (2017). “Development of a Healthy Aging Score in the Population-Based Rotterdam Study: Evaluating Age and Sex Differences.” Journal of the American Medical Directors Association, 18(3), 276.e1-276.e7. doi: 10.1016/j.jamda.2016.11.021 (URL:

Jen V, Erler NS, Tielemans MJ, Braun KV, Jaddoe VW, Franco OH, Voortman T (2017). “Mothers’ intake of sugar-containing beverages during pregnancy and body composition of their children during childhood: The Generation R Study.” The American Journal of Clinical Nutrition, 105(4), 834-841. doi: 10.3945/ajcn.116.147934 (URL:

Muka T, Blekkenhorst LC, Lewis JR, Prince RL, Erler NS, Hofman A, Franco OH, Rivadeneira F, Kiefte-de Jong JC (2017). “Dietary fat composition, total body fat and regional body fat distribution in two Caucasian populations of middle-aged and older adult women.” Clinical Nutrition, 36(5), 1411 - 1419. doi: 10.1016/j.clnu.2016.09.018 (URL:

Schoufour JD, Erler NS, Jaspers L, Kiefte-de Jong JC, Voortman T, Ziere G, Lindemans J, Klaver CC, Tiemeier H, Stricker B, Ikram AM, Laven JS, Brusselle GG, Rivadeneira F, Franco OH (2017). “Design of a frailty index among community living middle-aged and older people: The Rotterdam Study.” Maturitas, 97, 14-20. doi: 10.1016/j.maturitas.2016.12.002 (URL:

Braun KV, Erler NS, Kiefte-de Jong JC, Jaddoe VW, van den Hooven EH, Franco OH, Voortman T (2016). “Dietary Intake of Protein in Early Childhood Is Associated with Growth Trajectories between 1 and 9 Years of Age.” The Journal of Nutrition, 146(11), 2361-2367. doi: 10.3945/jn.116.237164 (URL:

Egal M, Erler NS, De Geus HR, Van Bommel J, Groeneveld JA (2016). “Targeting Oliguria Reversal in Goal-Directed Hemodynamic Management Does Not Reduce Renal Dysfunction in Perioperative and Critically Ill Patients: A Systematic Review and Meta-Analysis.” Anesthesia & Analgesia, 122(1), 173-185. doi: 10.1213/ANE.0000000000001027 (URL:

Erler NS, Rizopoulos D, van Rosmalen J, Jaddoe VW, Franco OH, Lesaffre EM (2016). “Dealing with missing covariates in epidemiologic studies: A comparison between multiple imputation and a full Bayesian approach.” Statistics in Medicine, 35(17), 2955-2974. doi: 10.1002/sim.6944 (URL:

Ophuis CMO, van Akkooi AC, Rutkowski P, Voit CA, Stepniak J, Erler NS, Eggermont AM, Wouters MW, Grünhagen DJ, Verhoef C (2016). “Effects of time interval between primary melanoma excision and sentinel node biopsy on positivity rate and survival.” European Journal of Cancer, 67, 164-173. doi: 10.1016/j.ejca.2016.08.014 (URL:

Leermakers ET, Felix JF, Erler NS, Cerimagic A, Wijtzes AI, Hofman A, Raat H, Moll HA, Rivadeneira F, Jaddoe VW, Franco OH, Kiefte-de Jong JC (2015). “Sugar-containing beverage intake in toddlers and body composition up to age 6 years: The Generation R Study.” European Journal of Clinical Nutrition, 69(3), 314-321. doi: 10.1038/ejcn.2015.2 (URL:

Tielemans MJ, Erler NS, Leermakers ET, van den Broek M, Jaddoe VW, Steegers EA, Kiefte-de Jong JC, Franco OH (2015). “A Priori and a Posteriori Dietary Patterns during Pregnancy and Gestational Weight Gain: The Generation R Study.” Nutrients, 7(11), 9383-9399. doi: 10.3390/nu7115476 (URL:

Erler NS, Bryan SR, Eilers PH, Lesaffre EM, Lemij HG, Vermeer KA (2014). “Optimizing Structure-Function Relationship by Maximizing Correspondence Between Glaucomatous Visual Fields and Mathematical Retinal Nerve Fiber Models.” Investigative Ophthalmology & Visual Science, 55(4), 2350-2357. doi: 10.1167/iovs.13-12492 (URL: